All Publications
. 2024
Yingli Gu, Alexander Pope, Charlene Smith, Christopher Carmona, Aaron Johnstone , Linda Shi, Xuqiao Chen, Sarai Santos, Claire Cecile Bacon-Brenes, Thomas Shoff b, Korbin M. Kleczko, Judith Frydman, Leslie M. Thompson, William C. Mobley, Chengbiao Wu. BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. 2024. Neurobiology of Disease
Available online 10 April 2024, 106502 In Press https://www.sciencedirect.com/science/article/pii/S0969996124001013?via%3Dihub
Sophia Barber, Veronica Gomez-Godinez, Joy Young, Abigail Wei, Sarah Chen, Anna Snissarenko, Sze Sze Chan, Chengbiao Wu, Linda Shi. Impacts of H2O2, SARM1 inhibition, and high NAm concentrations on Huntington's disease laser-induced degeneration
First published: 07 January 2024 https://doi.org/10.1002/jbio.202300370
2023
Erika Kropf, Arman Shekari, Sama Jaberi, Anish Puri, Chengbiao Wu, and Margaret Fahnestock. Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR. ront. Mol. Neurosci., 13 November 2023 Sec. Brain Disease Mechanisms Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1241420
Leitao, A.D.G., Spencer, B., Wu, C., Masliah, E. and Rissman, R.A. (2023), Novel systemic delivery of a peptide-mediated anti-sense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer’s Disease. Alzheimer's Dement., 19: e079022. https://doi.org/10.1002/alz.079022
Leitão, André D.G. Spencer, Brian, Sarsoza, Floyd, | Ngolab, Jennifer, Amalraj, Jessica, Masliah, Eliezer, Wu, Chengbiao, Rissman, Robert. AHippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer’s Disease Mice. July 2023Journal of Alzheimer's disease: JAD 95(1):1-14 DOI: 10.3233/JAD-230232
André D.G. Leitão, Rijwan U. Ahammad, Brian Spencer, Chengbiao Wu, Eliezer Masliah, Robert A. Rissman. Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease. Neurobiology of Disease Volume 186, 1 October 2023, 106285
Jessica Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald Pizzo, Jin Wang, Adela Malik, Timothy Shay, Erin Sullivan, Brent Aulston, Seung Song, Julia Callender, Henry Sanchez, Michael Geschwind, Subhojit Roy, Robert Rissman, JoAnn Trejo, Nobuyuki Tanaka, Chengbiao Wu, Xu Chen, Gentry Patrick, and Christina Sigurdson. 2023. Diminished neuronal ESCRT-0 function exacerbates AMPA receptor derangement and accelerates prion-induced neurodegeneration. J Neurosci. 2023 Apr 5:JN-RM-1878-22. doi: 10.1523/JNEUROSCI.1878-22.2023. Epub ahead of print. PMID: 37019623.
Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix, María Raquel Ibáñez, Alejandro A. Aguirre-Soto, Miguel V. Guerra, Chengbiao Wu, William C. Mobley, Eran Perlson, and Francisca C Bronfman*. BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons. Elife. 2023 Feb 24;12:e77455. doi: 10.7554/eLife.77455. PMID: 36826992; PMCID: PMC9977295.
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu. CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons. Nat Commun. 2023 Feb 8;14(1):692. doi: 10.1038/s41467-023-36096-w. PMID: 36754966; PMCID: PMC9908936.
Lin S, Leitão ADG, Fang S, Gu Y, Barber S, Gilliard-Telefoni R, Castro A, Sung K, Shen R, Florio JB, Mante ML, Ding J, Spencer B, Masliah E, Rissman RA, Wu C. Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy. Neurobiol Dis. 2023 Jan 23;:106010. doi: 10.1016/j.nbd.2023.106010. [Epub ahead of print] PubMed PMID: 36702318.
2022
Yu X, Yang Z, Zhang Y, Xia J, Zhang J, Han Q, Yu H, Wu C, Xu Y, Xu W, Yang W. Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy. Adv Healthc Mater. 2023 Jan;12(3):e2202127. doi: 10.1002/adhm.202202127. Epub 2022 Nov 18. PubMed PMID: 36325948.
Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, Cecilia Bucci3*, Chengbiao Wu* Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy . Commun Biol. 2022 Jul 18;5(1):717. doi: 10.1038/s42003-022-03632-1. PubMed PMID: 35851620; PubMed Central PMCID: PMC9293960
Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 Oct 1;172:105834. doi: 10.1016/j.nbd.2022.105834. Epub 2022 Jul 26. PubMed PMID: 35905927.
Shen R, Murphy CJ, Xu X, Hu M, Ding J, Wu C. Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases. Front Cell Dev Biol. 2022;10:824961. doi: 10.3389/fcell.2022.824961. eCollection 2022. Review. PubMed PMID: 35359443; PubMed Central PMCID: PMC8963869.
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PubMed PMID: 33634751.
Gomez Godinez V, Morar V, Carmona C, Gu Y, Sung K, Shi LZ, Wu C, Preece D and Berns MW (2021) Laser-Induced Shockwave (LIS) to Study Neuronal Ca2+ Responses. Front. Bioeng. Biotechnol. 9:598896. doi: 10.3389/fbioe.2021.598896
Yingli Gu, Alexander Pope, Charlene Smith, Christopher Carmona, Aaron Johnstone , Linda Shi, Xuqiao Chen, Sarai Santos, Claire Cecile Bacon-Brenes, Thomas Shoff b, Korbin M. Kleczko, Judith Frydman, Leslie M. Thompson, William C. Mobley, Chengbiao Wu. BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. 2024. Neurobiology of Disease
Available online 10 April 2024, 106502 In Press https://www.sciencedirect.com/science/article/pii/S0969996124001013?via%3Dihub
Sophia Barber, Veronica Gomez-Godinez, Joy Young, Abigail Wei, Sarah Chen, Anna Snissarenko, Sze Sze Chan, Chengbiao Wu, Linda Shi. Impacts of H2O2, SARM1 inhibition, and high NAm concentrations on Huntington's disease laser-induced degeneration
First published: 07 January 2024 https://doi.org/10.1002/jbio.202300370
2023
Erika Kropf, Arman Shekari, Sama Jaberi, Anish Puri, Chengbiao Wu, and Margaret Fahnestock. Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR. ront. Mol. Neurosci., 13 November 2023 Sec. Brain Disease Mechanisms Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1241420
Leitao, A.D.G., Spencer, B., Wu, C., Masliah, E. and Rissman, R.A. (2023), Novel systemic delivery of a peptide-mediated anti-sense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer’s Disease. Alzheimer's Dement., 19: e079022. https://doi.org/10.1002/alz.079022
Leitão, André D.G. Spencer, Brian, Sarsoza, Floyd, | Ngolab, Jennifer, Amalraj, Jessica, Masliah, Eliezer, Wu, Chengbiao, Rissman, Robert. AHippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer’s Disease Mice. July 2023Journal of Alzheimer's disease: JAD 95(1):1-14 DOI: 10.3233/JAD-230232
André D.G. Leitão, Rijwan U. Ahammad, Brian Spencer, Chengbiao Wu, Eliezer Masliah, Robert A. Rissman. Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease. Neurobiology of Disease Volume 186, 1 October 2023, 106285
Jessica Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald Pizzo, Jin Wang, Adela Malik, Timothy Shay, Erin Sullivan, Brent Aulston, Seung Song, Julia Callender, Henry Sanchez, Michael Geschwind, Subhojit Roy, Robert Rissman, JoAnn Trejo, Nobuyuki Tanaka, Chengbiao Wu, Xu Chen, Gentry Patrick, and Christina Sigurdson. 2023. Diminished neuronal ESCRT-0 function exacerbates AMPA receptor derangement and accelerates prion-induced neurodegeneration. J Neurosci. 2023 Apr 5:JN-RM-1878-22. doi: 10.1523/JNEUROSCI.1878-22.2023. Epub ahead of print. PMID: 37019623.
Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix, María Raquel Ibáñez, Alejandro A. Aguirre-Soto, Miguel V. Guerra, Chengbiao Wu, William C. Mobley, Eran Perlson, and Francisca C Bronfman*. BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons. Elife. 2023 Feb 24;12:e77455. doi: 10.7554/eLife.77455. PMID: 36826992; PMCID: PMC9977295.
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu. CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons. Nat Commun. 2023 Feb 8;14(1):692. doi: 10.1038/s41467-023-36096-w. PMID: 36754966; PMCID: PMC9908936.
Lin S, Leitão ADG, Fang S, Gu Y, Barber S, Gilliard-Telefoni R, Castro A, Sung K, Shen R, Florio JB, Mante ML, Ding J, Spencer B, Masliah E, Rissman RA, Wu C. Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy. Neurobiol Dis. 2023 Jan 23;:106010. doi: 10.1016/j.nbd.2023.106010. [Epub ahead of print] PubMed PMID: 36702318.
2022
Yu X, Yang Z, Zhang Y, Xia J, Zhang J, Han Q, Yu H, Wu C, Xu Y, Xu W, Yang W. Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy. Adv Healthc Mater. 2023 Jan;12(3):e2202127. doi: 10.1002/adhm.202202127. Epub 2022 Nov 18. PubMed PMID: 36325948.
Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, Cecilia Bucci3*, Chengbiao Wu* Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy . Commun Biol. 2022 Jul 18;5(1):717. doi: 10.1038/s42003-022-03632-1. PubMed PMID: 35851620; PubMed Central PMCID: PMC9293960
Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 Oct 1;172:105834. doi: 10.1016/j.nbd.2022.105834. Epub 2022 Jul 26. PubMed PMID: 35905927.
Shen R, Murphy CJ, Xu X, Hu M, Ding J, Wu C. Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases. Front Cell Dev Biol. 2022;10:824961. doi: 10.3389/fcell.2022.824961. eCollection 2022. Review. PubMed PMID: 35359443; PubMed Central PMCID: PMC8963869.
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PubMed PMID: 33634751.
Gomez Godinez V, Morar V, Carmona C, Gu Y, Sung K, Shi LZ, Wu C, Preece D and Berns MW (2021) Laser-Induced Shockwave (LIS) to Study Neuronal Ca2+ Responses. Front. Bioeng. Biotechnol. 9:598896. doi: 10.3389/fbioe.2021.598896
2020
Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C. A Missense Point Mutation in Nerve Growth Factor (NGFR100W) Results in Selective Peripheral Sensory Neuropathy. Prog Neurobiol. 2020 Jul 18;:101886. doi: 10.1016/j.pneurobio.2020.101886. [Epub ahead of print] PubMed PMID: 32693191.
Ruinan Shen; Xiaobei Zhao; Lu He; Yongbo Ding; Wei Xu; Suzhen Lin; Savannah Fang; Wanlin Yang; Kijung Sung; Brian Spencer; Robert A Rissman; Ming Lei; Jianqing Ding; Chengbiao Wu. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease. Transl Neurodegener. 2020 Jun 18;9(1):26. doi: 10.1186/s40035-020-00206-1. PubMed PMID: 32552912; PubMed Central PMCID: PMC7301499.Accepted for Translational Neurodegeneration
Li R, Li D, Wu C, Ye L, Wu Y, Yuan Y, Yang S, Xie L, Mao Y, Jiang T, Li Y, Wang J, Zhang H, Li X, Xiao J. Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. Theranostics. 2020;10(4):1649-1677. doi: 10.7150/thno.40919. eCollection 2020. PubMed PMID: 32042328; PubMed Central PMCID: PMC6993217.
Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C. A Missense Point Mutation in Nerve Growth Factor (NGFR100W) Results in Selective Peripheral Sensory Neuropathy. Prog Neurobiol. 2020 Jul 18;:101886. doi: 10.1016/j.pneurobio.2020.101886. [Epub ahead of print] PubMed PMID: 32693191.
Ruinan Shen; Xiaobei Zhao; Lu He; Yongbo Ding; Wei Xu; Suzhen Lin; Savannah Fang; Wanlin Yang; Kijung Sung; Brian Spencer; Robert A Rissman; Ming Lei; Jianqing Ding; Chengbiao Wu. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease. Transl Neurodegener. 2020 Jun 18;9(1):26. doi: 10.1186/s40035-020-00206-1. PubMed PMID: 32552912; PubMed Central PMCID: PMC7301499.Accepted for Translational Neurodegeneration
Li R, Li D, Wu C, Ye L, Wu Y, Yuan Y, Yang S, Xie L, Mao Y, Jiang T, Li Y, Wang J, Zhang H, Li X, Xiao J. Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration. Theranostics. 2020;10(4):1649-1677. doi: 10.7150/thno.40919. eCollection 2020. PubMed PMID: 32042328; PubMed Central PMCID: PMC6993217.
2019
Wenzel ED, Speidell A, Flowers SA, Wu C, Avdoshina V, Mocchetti I. Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Cell Death Dis. 2019 Sep 12;10(9):674. doi: 10.1038/s41419-019-1920-7. PubMed PMID: 31515470; PubMed Central PMCID: PMC6742654.
Bearer EL, Wu C. Herpes Simplex Virus, Alzheimer's Disease and a Possible Role for Rab GTPases. Front Cell Dev Biol. 2019;7:134. doi: 10.3389/fcell.2019.00134. eCollection 2019. PubMed PMID: 31448273; PubMed Central PMCID: PMC6692634.
Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 Apr 15;9(1):6070. doi: 10.1038/s41598-019-42420-6. PubMed PMID: 30988348; PubMed Central PMCID: PMC6465280.
Sung K, Yang W, Wu C. Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?. Neural Regen Res. 2019 Apr;14(4):570-573. doi: 10.4103/1673-5374.247442. Review. PubMed PMID: 30632491; PubMed Central PMCID: PMC6352596.
Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C. Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018;10:373. doi: 10.3389/fnagi.2018.00373. eCollection 2018. PubMed PMID: 30524266; PubMed Central PMCID: PMC6262302.
Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 Nov;19(11):840-853. doi: 10.1111/tra.12610. Epub 2018 Sep 12. PubMed PMID: 30120810; PubMed Central PMCID: PMC6191364.select
Wenzel ED, Speidell A, Flowers SA, Wu C, Avdoshina V, Mocchetti I. Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Cell Death Dis. 2019 Sep 12;10(9):674. doi: 10.1038/s41419-019-1920-7. PubMed PMID: 31515470; PubMed Central PMCID: PMC6742654.
Bearer EL, Wu C. Herpes Simplex Virus, Alzheimer's Disease and a Possible Role for Rab GTPases. Front Cell Dev Biol. 2019;7:134. doi: 10.3389/fcell.2019.00134. eCollection 2019. PubMed PMID: 31448273; PubMed Central PMCID: PMC6692634.
Escudero CA, Cabeza C, Moya-Alvarado G, Maloney MT, Flores CM, Wu C, Court FA, Mobley WC, Bronfman FC. c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Sci Rep. 2019 Apr 15;9(1):6070. doi: 10.1038/s41598-019-42420-6. PubMed PMID: 30988348; PubMed Central PMCID: PMC6465280.
Sung K, Yang W, Wu C. Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?. Neural Regen Res. 2019 Apr;14(4):570-573. doi: 10.4103/1673-5374.247442. Review. PubMed PMID: 30632491; PubMed Central PMCID: PMC6352596.
Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C. Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018;10:373. doi: 10.3389/fnagi.2018.00373. eCollection 2018. PubMed PMID: 30524266; PubMed Central PMCID: PMC6262302.
Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 Nov;19(11):840-853. doi: 10.1111/tra.12610. Epub 2018 Sep 12. PubMed PMID: 30120810; PubMed Central PMCID: PMC6191364.select
2018
Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 Apr 4;38(14):3394-3413. doi: 10.1523/JNEUROSCI.1686-17.2018. Epub 2018 Feb 26. PubMed PMID: 29483280; PubMed Central PMCID: PMC5895035.
Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr;120(4):745-760. doi: 10.1016/j.bja.2017.12.033. Epub 2018 Feb 15. PubMed PMID: 29576115.
Xu W, Fang F, Ding J, Wu C. Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease. Traffic. 2018 Apr;19(4):253-262. doi: 10.1111/tra.12547. Epub 2018 Feb 5. Review. PubMed PMID: 29314494; PubMed Central PMCID: PMC5869093.
Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, Wei N, Liu Z, Zhou J, Burgess RW, Pfaff SL, Caskey CT, Wu C, Bai G, Yang XL. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018 Mar 8;9(1):1007. doi: 10.1038/s41467-018-03461-z. PubMed PMID: 29520015; PubMed Central PMCID: PMC5843656.
Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 Apr 4;38(14):3394-3413. doi: 10.1523/JNEUROSCI.1686-17.2018. Epub 2018 Feb 26. PubMed PMID: 29483280; PubMed Central PMCID: PMC5895035.
Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr;120(4):745-760. doi: 10.1016/j.bja.2017.12.033. Epub 2018 Feb 15. PubMed PMID: 29576115.
Xu W, Fang F, Ding J, Wu C. Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease. Traffic. 2018 Apr;19(4):253-262. doi: 10.1111/tra.12547. Epub 2018 Feb 5. Review. PubMed PMID: 29314494; PubMed Central PMCID: PMC5869093.
Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, Wei N, Liu Z, Zhou J, Burgess RW, Pfaff SL, Caskey CT, Wu C, Bai G, Yang XL. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018 Mar 8;9(1):1007. doi: 10.1038/s41467-018-03461-z. PubMed PMID: 29520015; PubMed Central PMCID: PMC5843656.
2017
Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Sci Rep. 2017 Jun 20;7(1):3868. doi: 10.1038/s41598-017-04232-4. PubMed PMID: 28634349; PubMed Central PMCID: PMC5478665.
Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 Apr 21;5(1):32. doi: 10.1186/s40478-017-0430-z.
Liu H, Wu C. Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling? Int J Mol Sci. 2017 Feb 4;18(2). pii: E324. doi: 10.3390/ijms18020324. Review.
Plotkin JL, Wu C. Neurotrophin biology at NGF 2016: From fundamental science to clinical applications. Int J Dev Neurosci. 2017 Feb;56:27-34. doi: 10.1016/j.ijdevneu.2016.11.005. Epub 2016 Nov 22. Review.
Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Sci Rep. 2017 Jun 20;7(1):3868. doi: 10.1038/s41598-017-04232-4. PubMed PMID: 28634349; PubMed Central PMCID: PMC5478665.
Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 Apr 21;5(1):32. doi: 10.1186/s40478-017-0430-z.
Liu H, Wu C. Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling? Int J Mol Sci. 2017 Feb 4;18(2). pii: E324. doi: 10.3390/ijms18020324. Review.
Plotkin JL, Wu C. Neurotrophin biology at NGF 2016: From fundamental science to clinical applications. Int J Dev Neurosci. 2017 Feb;56:27-34. doi: 10.1016/j.ijdevneu.2016.11.005. Epub 2016 Nov 22. Review.
2016
Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6.
Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 Jul 27;36(30):7971-84. doi: 10.1523/JNEUROSCI.0775-16.2016.
Xu W, Weissmiller AM, White JA 2nd, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 May 2;126(5):1815-33. doi: 10.1172/JCI82409. Epub 2016 Apr 11.
Le MH, Weissmiller AM, Monte L, Lin PH, Hexom TC, Natera O, Wu C, Rissman RA. Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One. 2016 Jan 20;11(1):e0147250. doi: 10.1371/journal.pone.0147250. eCollection 2016. PubMed PMID: 26790099; PubMed Central PMCID: PMC4720402.
2015
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2015 Sep 2;87(5):963-75. doi: 10.1016/j.neuron.2015.08.020. PubMed PMID: 26335643; PubMed Central PMCID: PMC4575284.
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015. PubMed PMID: 25710492; PubMed Central PMCID: PMC4339551.
2014
Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15;(91):51899. doi: 10.3791/51899. PubMed PMID: 25286194; PubMed Central PMCID: PMC4828072.
Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun 1;74(11):3127-36. doi: 10.1158/0008-5472.CAN-13-3213. Epub 2014 Apr 22. PubMed PMID: 24755468; PubMed Central PMCID: PMC4047720.
Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12;(84):e50783. doi: 10.3791/50783. PubMed PMID: 24561719; PubMed Central PMCID: PMC4089403.
2013
Zhang K, Fishel Ben Kenan R, Osakada Y, Xu W, Sinit RS, Chen L, Zhao X, Chen JY, Cui B, Wu C. Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling. J Neurosci. 2013 Apr 24;33(17):7451-62. doi: 10.1523/JNEUROSCI.4322-12.2013. PubMed PMID: 23616551; PubMed Central PMCID: PMC3722856.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr;19(4):473-80. doi: 10.1038/nm.3117. Epub 2013 Mar 24. PubMed PMID: 23524343; PubMed Central PMCID: PMC3911880.
2012
Weissmiller AM, Wu C. Current advances in using neurotrophic factors to treat neurodegenerative disorders.
Transl Neurodegener. 2012 Jul 26;1(1):14. doi: 10.1186/2047-9158-1-14. PubMed PMID: 23210531; PubMed Central PMCID: PMC3542569.
Chen L, Holman HY, Hao Z, Bechtel HA, Martin MC, Wu C, Chu S. Synchrotron infrared measurements of protein phosphorylation in living single PC12 cells during neuronal differentiation. Anal Chem. 2012 May 1;84(9):4118-25. doi: 10.1021/ac300308x. Epub 2012 Apr 18. PubMed PMID: 22468902.
Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X, Bao L. Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res. 2012 Apr;22(4):677-96. doi: 10.1038/cr.2011.197. Epub 2011 Dec 13. PubMed PMID: 22157653; PubMed Central PMCID: PMC3317558.
Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, Militz D, Schmidt V, Madsen P, Nyengaard JR, Willnow TE, Christensen EI, Mobley WB, Nykjær A, Andersen OM. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci. 2012 Jan 25;32(4):1467-80. doi: 10.1523/JNEUROSCI.2272-11.2012. PubMed PMID: 22279231.
2011
Sung K, Maloney MT, Yang J, Wu C. A novel method for producing mono-biotinylated, biologically active neurotrophic factors: an essential reagent for single molecule study of axonal transport. J Neurosci Methods. 2011 Sep 15;200(2):121-8. doi: 10.1016/j.jneumeth.2011.06.020. Epub 2011 Jul 2. PubMed PMID: 21756937; PubMed Central PMCID: PMC3158612.
Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6.
Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 Jul 27;36(30):7971-84. doi: 10.1523/JNEUROSCI.0775-16.2016.
Xu W, Weissmiller AM, White JA 2nd, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 May 2;126(5):1815-33. doi: 10.1172/JCI82409. Epub 2016 Apr 11.
Le MH, Weissmiller AM, Monte L, Lin PH, Hexom TC, Natera O, Wu C, Rissman RA. Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One. 2016 Jan 20;11(1):e0147250. doi: 10.1371/journal.pone.0147250. eCollection 2016. PubMed PMID: 26790099; PubMed Central PMCID: PMC4720402.
2015
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 2015 Sep 2;87(5):963-75. doi: 10.1016/j.neuron.2015.08.020. PubMed PMID: 26335643; PubMed Central PMCID: PMC4575284.
Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10(2):e0118379. doi: 10.1371/journal.pone.0118379. eCollection 2015. PubMed PMID: 25710492; PubMed Central PMCID: PMC4339551.
2014
Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15;(91):51899. doi: 10.3791/51899. PubMed PMID: 25286194; PubMed Central PMCID: PMC4828072.
Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun 1;74(11):3127-36. doi: 10.1158/0008-5472.CAN-13-3213. Epub 2014 Apr 22. PubMed PMID: 24755468; PubMed Central PMCID: PMC4047720.
Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12;(84):e50783. doi: 10.3791/50783. PubMed PMID: 24561719; PubMed Central PMCID: PMC4089403.
2013
Zhang K, Fishel Ben Kenan R, Osakada Y, Xu W, Sinit RS, Chen L, Zhao X, Chen JY, Cui B, Wu C. Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling. J Neurosci. 2013 Apr 24;33(17):7451-62. doi: 10.1523/JNEUROSCI.4322-12.2013. PubMed PMID: 23616551; PubMed Central PMCID: PMC3722856.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr;19(4):473-80. doi: 10.1038/nm.3117. Epub 2013 Mar 24. PubMed PMID: 23524343; PubMed Central PMCID: PMC3911880.
2012
Weissmiller AM, Wu C. Current advances in using neurotrophic factors to treat neurodegenerative disorders.
Transl Neurodegener. 2012 Jul 26;1(1):14. doi: 10.1186/2047-9158-1-14. PubMed PMID: 23210531; PubMed Central PMCID: PMC3542569.
Chen L, Holman HY, Hao Z, Bechtel HA, Martin MC, Wu C, Chu S. Synchrotron infrared measurements of protein phosphorylation in living single PC12 cells during neuronal differentiation. Anal Chem. 2012 May 1;84(9):4118-25. doi: 10.1021/ac300308x. Epub 2012 Apr 18. PubMed PMID: 22468902.
Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X, Bao L. Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res. 2012 Apr;22(4):677-96. doi: 10.1038/cr.2011.197. Epub 2011 Dec 13. PubMed PMID: 22157653; PubMed Central PMCID: PMC3317558.
Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, Militz D, Schmidt V, Madsen P, Nyengaard JR, Willnow TE, Christensen EI, Mobley WB, Nykjær A, Andersen OM. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci. 2012 Jan 25;32(4):1467-80. doi: 10.1523/JNEUROSCI.2272-11.2012. PubMed PMID: 22279231.
2011
Sung K, Maloney MT, Yang J, Wu C. A novel method for producing mono-biotinylated, biologically active neurotrophic factors: an essential reagent for single molecule study of axonal transport. J Neurosci Methods. 2011 Sep 15;200(2):121-8. doi: 10.1016/j.jneumeth.2011.06.020. Epub 2011 Jul 2. PubMed PMID: 21756937; PubMed Central PMCID: PMC3158612.